Interruption of deep brain stimulation of the globus pallidus in primary generalized dystonia
Identifieur interne : 002247 ( Main/Exploration ); précédent : 002246; suivant : 002248Interruption of deep brain stimulation of the globus pallidus in primary generalized dystonia
Auteurs : David Grabli [France] ; Claire Ewenczyk [France] ; Maria-Clara Coelho-Braga [France] ; Christelle Lagrange [France] ; Valerie Fraix [France] ; Philippe Cornu [France] ; Alim-Louis Benabid [France] ; Marie Vidailhet [France] ; Pierre Pollak [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-12-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Deep Brain Stimulation (methods), Deep brain stimulation, Disability Evaluation, Double-Blind Method, Dystonia, Dystonia (therapy), Female, Globus Pallidus (physiology), Humans, Male, Middle Aged, Nervous system diseases, Safety, Severity of Illness Index, Time Factors, Young Adult, dystonia, globus pallidus, neurostimulation, safety.
- MESH :
- methods : Deep Brain Stimulation.
- physiology : Globus Pallidus.
- therapy : Dystonia.
- Adult, Disability Evaluation, Double-Blind Method, Female, Humans, Male, Middle Aged, Severity of Illness Index, Time Factors, Young Adult.
Abstract
Stimulation (DBS) of the globus pallidus (GP) is effective to treat generalized dystonia. Little is known about the evolution of dystonia in case of arrest after a long period of stimulation. This study describes the course of dystonia during a 48 hours period without stimulation followed by a 24 hours period after turning ON the stimulator. 14 patients with generalized dystonia treated with bilateral GP DBS for 3 years or more were recruited. Blinded video‐based analysis was performed using Burke‐Fahn‐Marsden scale at (1) baseline (ON stimulation), (2) up to 48 hours after the stimulator was turned OFF, and (3) 24 hours after the stimulator was turned ON. 13 patients completed the 48 hours OFF‐stimulation period. The dystonia movement score progressively worsened from 24.3 ± 13.9 at baseline to 48.9 ± 19.8 after 48 hours (P < 0.00001). The disability score also worsened from 4.4 ± 1.2 at baseline to 5.7 ± 1.5 after 48 hours without stimulation (P < 0.001). When the neurostimulator was turned ON, the dystonia scores returned to baseline level after 10 hours. The interruption of GP DBS in dystonia results in a progressive worsening which is rapidly reversible once the neurostimulator is turned ON. © 2009 Movement Disorder Society
Url:
- https://api.istex.fr/document/8C728BFE38077847404BF074D1C269ADB49E5230/fulltext/pdf
- http://www.hal.inserm.fr/inserm-00529166
DOI: 10.1002/mds.22827
Affiliations:
- France
- Auvergne-Rhône-Alpes, Rhône-Alpes
- Grenoble, Paris
- Centre hospitalier universitaire Grenoble Alpes
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Le document en format XML
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Little is known about the evolution of dystonia in case of arrest after a long period of stimulation. This study describes the course of dystonia during a 48 hours period without stimulation followed by a 24 hours period after turning ON the stimulator. 14 patients with generalized dystonia treated with bilateral GP DBS for 3 years or more were recruited. Blinded video‐based analysis was performed using Burke‐Fahn‐Marsden scale at (1) baseline (ON stimulation), (2) up to 48 hours after the stimulator was turned OFF, and (3) 24 hours after the stimulator was turned ON. 13 patients completed the 48 hours OFF‐stimulation period. The dystonia movement score progressively worsened from 24.3 ± 13.9 at baseline to 48.9 ± 19.8 after 48 hours (P < 0.00001). The disability score also worsened from 4.4 ± 1.2 at baseline to 5.7 ± 1.5 after 48 hours without stimulation (P < 0.001). When the neurostimulator was turned ON, the dystonia scores returned to baseline level after 10 hours. The interruption of GP DBS in dystonia results in a progressive worsening which is rapidly reversible once the neurostimulator is turned ON. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li><li>Paris</li></settlement><orgName><li>Centre hospitalier universitaire Grenoble Alpes</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Grabli, David" sort="Grabli, David" uniqKey="Grabli D" first="David" last="Grabli">David Grabli</name></noRegion><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><name sortKey="Coelho Raga, Maria Lara" sort="Coelho Raga, Maria Lara" uniqKey="Coelho Raga M" first="Maria-Clara" last="Coelho-Braga">Maria-Clara Coelho-Braga</name><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name><name sortKey="Ewenczyk, Claire" sort="Ewenczyk, Claire" uniqKey="Ewenczyk C" first="Claire" last="Ewenczyk">Claire Ewenczyk</name><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><name sortKey="Grabli, David" sort="Grabli, David" uniqKey="Grabli D" first="David" last="Grabli">David Grabli</name><name sortKey="Lagrange, Christelle" sort="Lagrange, Christelle" uniqKey="Lagrange C" first="Christelle" last="Lagrange">Christelle Lagrange</name><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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